ea0041ep917 | Pituitary - Clinical | ECE2016
Turgut Seda
, Ilhan Muzaffer
, Turan Saime
, Karaman Ozcan
, Yaylim Ilhan
, Kucukhuseyin Ozlem
, Tasan Ertugrul
Introduction: Prolactinomas are thought to arise from the proliferation of a mutated pituitary stem cell which is subjected to the growth stimuli of several permissive factors, although the pathogenetic mechanisms underlying the tumorigenesis still remain unclear. The present study aimed to investigate the role of p16 (540C→G and 580C→T) and MDM2 (SNP309T→G) gene polymorphisms in tumorigenesis and characteristics of prolactinoma.Methods...